Fully Automated Classical SPR
For Humans, Systems, and Machines.
- No more late nights at the lab.
- No more missed lunches optimizing an assay.
- No-fuss fluidics. Right to repair.
- No SPR expertise needed — the device has it.
- Machines can design and run a classical SPR assay — an industry first.
Every angle, engineered.
Classical SPR, reimagined.
Full kinetic characterization with real-time ka, kd, and KD determination. The gold standard for label-free interaction analysis — with full automation from sample prep to analyzed results.
Lab partner on-board.
Integrated autosampler with de-capper, 4-axis robotic access, and 2 MTP-format nest locations. Temperature-controlled sample zone and 8-position chip storage with gripper-optimized access. Load your samples and walk away.
On-board intelligence
Edge compute designs experiments, optimizes assays, and maintains full traceability. No control PC required.
Right to repair
User-serviceable microfluidics designed for long service life and field maintenance. Your consumables work on day one.
Always connected
LAN or WiFi. 5 years on-device storage. 4 bulk reagent lines, 3 buffer lines, and 1 DI water line.
Automation
- Autosampler
- Integrated with on-board de-capper
- Robotic Access
- 4-axis, 4 degrees of nest access
- Sample Nests
- 2 MTP-format locations
- Chip Storage
- 8-position, gripper-optimized
- Chip Compatibility
- Biacore Series S style (Xantec)
Intelligence
- Compute
- On-board edge processing
- Experiment Design
- Autonomous
- Assay Optimization
- Autonomous regeneration selection
- Cameras
- 4 on-board, always accessible
- Control
- Touchscreen + browser, no PC required
Connectivity
- Network
- LAN or WiFi
- Data Storage
- 5 years on-device
- Reagent Lines
- 4 bulk + 3 buffer + 1 DI water
- Interface
- Browser-based, no software install
Serviceability
- Microfluidics
- User-serviceable, field maintainable
- Consumables
- Existing protocols and reagents
- Footprint
- 535 x 250 x 530 mm
Designed for the next decade of breakthroughs.
Autonomous kinetic characterization from screening through full multi-concentration analysis. The device designs, executes, and evaluates — you get publication-ready results.
Gold standard kinetic performance.
Sub-picomolar affinity resolution, no molecular weight limitation, and a purpose-built 1-on-7 flow cell for the highest quality interaction data.
Kinetic Performance
- KD Range
- 1E-3 to 1E-12 M
- ka (proteins)
- < 3E9 M⁻¹s⁻¹
- ka (small molecules)
- < 5E7 M⁻¹s⁻¹
- kd
- 1E-5 to 1 s⁻¹
- Molecular Weight
- No lower limit
- Sensitivity (RMSD)
- 0.02 RU
Temperature
- Sample Zone
- Ambient, 8 °C w/ chiller
- Reaction Zone
- 25 – 37 °C
Sample Delivery
- Flow Cell
- 1 on 7
- Flow Cell Volume
- 50 nL
- Max Injection Volume
- 1 mL
- Sample Loops
- 2
- Flow Paths
- 7
- Flow Rate
- 5 – 300 µL/min
- Data Rate
- 1 – 50 Hz
Physical
- Dimensions (H × W × D)
- 535 × 250 × 530 mm
- Needles
- 1
Every experiment is an API call.
Browser-based. No software to install. Connect from any device on your network.
Speak every protocol
Python SDK. REST API. SiLA2. MCP server. Natural language. SPRneo speaks every protocol your stack needs.
from instromeda import SPRneo
neo = SPRneo("sprneo-7.local")
result = neo.measure(
goal="binding_kinetics",
ligands=[
{"name": "EGFR-ECD", "features": ["biotinylated"]},
{"name": "HER2-ECD", "features": ["biotinylated"]}
],
analytes=scfv_panel,
chip_type="SA"
)
result.summary()Agent-ready
SPRneo exposes a lightweight MCP server — the device carries the intelligence, so any AI agent can design experiments, queue runs, and retrieve results with simple tool calls.
Scale on your terms
Design one experiment, deploy it anywhere. Multiple devices swarm a larger study, or run independent projects in parallel — all from the same interface.
One SPRneo runs the full study — screen, optimize, and characterize — sequentially.
See what accessible biophysics actually looks like.
We'll run a binding experiment live — on your molecules if you bring them. No canned demo. No slide deck.
Request a Demo